A novel method for cyanide quantification in human whole blood using ion chromatography with amperometric detection and its application to cyanide intoxication cases

Cyanide is a highly toxic agent that has been frequently used for suicide in South Korea. It is also used in various industrial fields, such as metal plating, in which many accidental cyanide intoxications have occurred. To overcome the disadvantages of conventional cyanide analysis methods, a simple and fast method for the analysis of cyanide in whole blood using ion chromatography (IC) with amperometric detection was developed in this study. Whole blood samples were deproteinized, diluted, and analyzed using an IC–amperometric detection system. The limits of detection and quantitation were 0.1 and 0.2 mg/L, respectively. The method showed good linearity in the range of 0.2 to 50 mg/L with R² > 0.99. The intra- and inter-assay precision and accuracy values were <10%. The established method was successfully applied to analyze whole blood samples from three cyanide intoxication cases.     

新时代我国现代化产业体系构建的工业化逻辑及其实现路径

现代化产业体系是现代化经济体系的重要组成部分,是指产业发展的新型化、产业结构的高级化、产业发展的集聚化和产业竞争力的高端化。从新时代经济发展的现实状态来看,我国现代化产业体系的构建必须坚持工业化的逻辑。坚持工业化逻辑就是要防止过度去工业化,从新兴产业的新动能培育与传统产业的新旧动能转换两条路径入手,以新型工业化、再工业化、继续工业化及工业现代化为基本逻辑,在坚持把实体经济做优做强的基础上,通过创新为我国工业化发展提供核心动力,进而构建我国新时代的现代化产业体系。现代化产业体系构建的工业化逻辑的实现需要发挥现代信息技术对产业发展的渗透作用,以信息化带动传统产业的现代化,加快战略性新兴产业的发展;推进供给侧结构性改革,积极培育现代化产业体系的新动能;推动消费结构升级,积极培育未来新产业的发展;完善支持体系,创造现代化产业体系构建的环境。     

Sample Mining and Data Mining: Combined Real-Time and Retrospective Approaches for the Identification of Emerging Novel Psychoactive Substances

Novel psychoactive substances (NPS) are synthetic drugs that pose serious public health and safety concerns. A multitude of NPS have been identified in the United States, often implicated in forensic investigations. The most common and effective manner for identifying NPS is by use of mass spectrometry and the true utility lies within nontargeted acquisition techniques. During this study, a liquid chromatography quadrupole time-of-flight mass spectrometry (LC-QTOF-MS) assay was developed, validated, and implemented for forensic toxicology testing. A SCIEX TripleTOF™ 5600 + with SWATH^® acquisition was used. Resulting data were compared against an extensive library database containing more than 800 compounds. The LC-QTOF-MS assay was applied to the reanalysis of biological sample extracts to discover emergent NPS. More than 3,000 sample extracts were analyzed, and more than 20 emerging NPS were detected for the first time. Among these were isopropyl-U-47700, 3,4-methylenedioxy-U-47700, fluorofuranylfentanyl, N-methyl norfentanyl, 2F-deschloroketamine, 3,4-methylenedioxy-alpha-PHP, eutylone, and N-ethyl hexedrone.     

全覆盖预算绩效管理的内容建构和路径探讨

经济新常态下,预算绩效管理已不再仅是对支出效率评估的工具,而是成为了实现国家治理现代化的保障机制。全覆盖预算绩效管理作为构建预算绩效管理体系的重要组成部分,以目标导向为原则,一方面旨在弥补传统预算绩效中存在的问题,另一方旨在构建起包括一般公共预算绩效管理体系、其它政府预算绩效管理体系和解决政府与社会企业的"五种合作模式"存在的部分问题的预算绩效管理体系。为推动全覆盖预算绩效管理的践行,应积极推进全覆盖与全方位预算绩效管理格局紧密配合、与全过程预算绩效管理链条有机联动的路径机制。同时,弥补全覆盖预算绩效管理相关的法律不足、建立健全全覆盖预算绩效考评监督体系等相关配套措施的顶层设计,从而推进"绩效管理平面化"向"绩效管理立体化"转变、实现财政支出效率和预算绩效管理的战略规划目标。     

Red Tape,Rule Burden,and Legitimate Performance Trade-Offs: Results from a Vignette Experiment

Abstract

Goals in the public sector are complex and managers can face situations in which pursuing one legitimate goal necessitates performance trade-offs in other areas. This study tests how knowledge of legitimate performance trade-offs shapes the perception of red tape. Using a vignette experimental design and a sample of university students, between group t-tests and regression analyses suggest that, when evaluating increased rule burden, individuals that are provided with information about how objectively burdensome rules serve alternative values such as equity and effectiveness associate them with lower levels of red tape. A series of Monte Carlo simulations suggest that this effect is substantial.     

论科学发展观视野中的地方政府绩效评价体系的优化

科学发展观的提出受到各界的普遍关注并得到了高度的评价。为确保科学发展观的贯彻落实,地方政府绩效评价体系的优化显得尤其重要。首先,要按照科学发展观的要求,构建科学的评价指标体系;其次,要完善评价主体结构;再次,要开发利用科学的评价技术与方法;最后,必须制定完善的法律法规,规范地方政府绩效评价活动。     

死者生前债务法律处置初探

我国实行限定继承的继承制度,又采取的是直接继承的方式,在缺乏对继承人有效监督的情况下,对债权人的保护极为不利,有必要对继承人予以限制。死者生前和死后都可能达成债务承担协议,实现债务全部或部分转移。由此,极可能引发纠纷。这些问题又恰恰是法律所未规定或规定不全面而为司法实践所常见者。因此从解决实际问题出发,本文对此略作探讨。     

High performance liquid chromatographic determination of alcohols with reference to body distribution of methanol

A method has been developed on reverse phase high performance liquid chromatography for simultaneous determination of methyl, ethyl and isopropyl alcohols under refractive index detection using pure water as the mobile phase. A good separation has been achieved between these alcohols. Detector response was linear with a detection limit of 5 mg/100 ml. Recovery studies were performed by adding known amounts of methyl and ethyl alcohols to blood, lung and liver within the range 80–90%. The reproducibility of the results was always >90%. The quantitative distribution of methyl alcohol in postmortem body tissues and fluids has been reported in three cases of poisoning.     

欧洲银行监管委员会《外包标准》(建议稿)介评 ——兼论我国金融外包监管法之完善

金融外包给金融风险监管提出了新的要求.有鉴于此,欧洲银行监管委员会先后出台了两份建议稿试图为银行业务外包风险监管在欧盟的框架内提供统一的指导原则.名为<外包标准>的建议稿是在<外包高级原则>(建议稿)的基础上于2006年4月出台的,二者在名称及具体内容上都有较大的不同.<外包标准>建议稿在保留第1份建议稿特色的基础上,强调了对客户金融隐私的保护,修正了金融监管部门对外包的监管权,使外包业务的分类更加明确.但是,现行建议稿在监管标准的制订上未充分考虑不同种类的外包商可能对外包风险造成的影响,要求所有的外包都必须有服务水平协议也较为绝对化.参考欧洲银行监管委员会在金融外包监管方面的立法经验,考虑我国金融外包的实践,我国应当制定普遍的金融外包监管法,同时对<电子银行业务管理办法>中电子银行业务外包部分进行完善.     

The effect of board size and composition on European bank performance

Banks are “special” financial institutions generating distinct corporate governance challenges. The present paper examines the relationship between two of the most pertinent corporate governance factors—that is, the size of the Board of Directors and the proportion of non-executive directors—and firm performance on a sample of 58 large European banks over the period 2002–2004. The empirical analysis embraces a number of bank-specific variables. Our results reveal that bank profitability is negatively related to the size of the Board of Directors, while the impact of Board composition, although positive in all models, is, in most cases, insignificant. The results are robust after controlling for firm-specific variables.